 A new version of the protein structure viewer Cn3D is now available. New features in Cn3D 2.5 include more user-friendly controls, improved editing and display options, and one-click installation. More...
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September 1999 |
 A recent publication by Eugene Koonin et al. at NCBI suggests that several protein domains involved in DNA repair have been conserved throughout evolution. The DNA repair proteins from E. coli and brewer's yeast were compared to proteins from the complete genomes of organisms from all three of the superkingdoms of life. More...
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September 1999 |
 10,000 candidate single nucleotide polymorphisms (SNPs) have been mined from the National Cancer Institute's cancer genome anatomy project (CGAP) and added to the SNP database. The CGAP candidates have been mapped to gene sequences in LocusLink and Entrez where possible. More...
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September 1999 |
 GenBank is 3 billion bases big! The National Institutes of Health hosts GenBank, the genetic sequence database. While DNA sequences for over 25,000 organisms are represented, most sequence data is from human (51%), mouse (9%) and the worm, Caenorhabditis elegans, (7%). More...
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September 1999 |
 The new version of the Entrez integrated search system incorporates PubMed, Genome, Nucleotide, Protein, Structure, and PopSet - a new database of DNA population studies. Added features include search history and a clipboard, plus Links Out to information providers. Be bold! Try it!
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October 1999 |
 Clusters of Orthologous Groups (COGs) now incorporates 21 complete genomes, tripling the number of organisms represented. COGs can now be searched by full text, protein/gene name as well as phylogenetic patterns.
On-line help is now available.
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October 1999 |
 NCBI's A. Panchenko, A. Marchler-Bauer, and S. Bryant came first out of 98 groups in the fold-recognition category at the most recent meeting on the Critical Assessment of Techniques for Protein Structure Prediction (CASP3). More...
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October 1999 |
 A segment of DNA sequence from chromosome 22 becomes the first human continuous sequence over 10 Mb in length. The Sanger Centre, Washington University, and the University of Oklahoma each contributed to this sequence.
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October 1999 |
 VecScreen, NCBI's newest tool, helps find vector contamination in DNA sequences. Use VecScreen to check for contamination before analyzing your sequence or submitting it to a database. More ...
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November 1999 |
 Celera is making sequence data from the fly genome available in a series of releases. This preliminary data can be searched using BLAST before the finishing and annotation phases of the project are complete. More ...
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November 1999 |
 The new version of the Entrez integrated search system incorporates PubMed, Genome, Nucleotide, Protein, Structure, and PopSet - a new database of DNA population studies. Added features include search history and a clipboard, plus Links Out to information providers. Be bold! Try it!
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December 1999 |
 The amount of human DNA deposited in GenBank surpassed one billion base pairs. This represents about one-third of the 3.2 billion base pairs believed to make-up the entire human genetic code, keeping the Human Genome Project on target for completion in 2003.
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December 1999 |
 Biologists at the National Institute of Allergy and Infectious Diseases, in collaboration with researchers at NCBI, have produced a genetic map of the human malaria parasite, Plasmodium falciparum.
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December 1999 |
 The SNP Consortium, made-up of the Wellcome Trust and 11 pharmaceutical companies, has made its first contribution to NCBI's database of single nucleotide polymorphisms (SNPs). This initial submission was for 2,562 SNPs bringing the size of dbSNPs to 21,134 - an increase of almost 14%.
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December 1999 |
 NCBI now offers a collection of eukaryotic organelle genome sequences as part of RefSeq. A reference sequence has been manually curated for each animal mitochondrion record and includes standardized gene, protein, and RNA names.
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January 2000 |
 A new version of Bankit, the Web tool for simple GenBank submissions, has been released. Bankit 3.0 has many added features including more robust validation checks, suggestions for coding region's intervals, and vector contamination screening.
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January 2000 |
 IgBLAST facilitates immunoglobulin sequence similarity searches. It identifies germline V, D, and J genes, annotates immunoglobulin domains, and matches sequences retrieved from the nr database to the closest germline V genes.
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January 2000 |
 LocusLink as been expanded to include mouse and rat genes, in addition to human. A single query interface, LocusLink provides a gateway to information on gene maps, phenotypes, nomenclature, reference sequences and related resources.
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January 2000 |
 Molecular Biology of the Cell, the molecular cell biology textbook by Alberts et al., has been adapted for the Web and linked to PubMed. It will serve as background information for PubMed searches. More books will be linked in the future.
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January 2000 |
 The NCBI BLAST group has developed IMPALA - software to match a protein sequence against a library of score matrices stored from PSI-BLAST. Any protein can be searched against a library of score matrices derived from the Blocks database via a Web service at the Fred Hutchinson Cancer Center.
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February 2000 |
 The number of base pairs in Entrez Nucleotide has surpassed five billion. Part of the Entrez search and retrieval system, the Nucleotide database contains sequence data from the international collaboration of sequence databases, including GenBank.
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February 2000 |
 Over 1.5 million base pairs long, the complete sequence of the food-borne pathogen, Campylobacter jejuni, was published in the February 10, 2000 issue of Nature and deposited in GenBank. C. jejuni is the leading cause of food poisoning worldwide.
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March 2000 |
HomoloGene is a new service which compares the nucleotide sequences between pairs of organisms, including human, mouse, rat, and zebrafish, in order to identify putative orthologs. Curated orthologs are incorporated from a variety of sources via LocusLink.
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April
2000 |
 Tax BLAST is a new service which groups BLAST hits by source organism, according to NCBI's Taxonomy database. Species are listed in order of sequence similarity with the query sequence - the strongest match listed first. Three report views are available.
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May
2000 |
 A new version of the protein structure viewer Cn3D is now available. Cn3D version 3.0 offers better graphics, improved sequence and alignment viewers, coloring by sequence alignment conservation, and one-click installation. More...
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June
2000 |
 The NCBI Map Viewer presents a graphical view of the Human Genome annotated with known genes, STSs, and SNPs. Get a first hand look at the finished and draft sequences from the human genome! More...
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July
2000 |
 A BLAST tutorial and information guide are now available to help both the novice and experienced BLAST user set up and perform a BLAST search, decipher the output and analyze the results. A PSI-BLAST tutorial and other resources are also available.
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July
2000 |
 By comparing the complete genomes of two pathogenic bacteria - Borrelia burgdorferi, which causes Lyme disease, and Treponema pallidum, which causes syphilis - NCBI scientists recently determined how these bacteria may have evolved along divergent biological paths.
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July
2000 |
